Abstract: Objective:To investigate the application value of laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation.Methods:In 48 cases with gastroduodenal ulcer perforation,18 cases were repaired by laparoscopy(laparoscpy group) and 30 cases were treated with laparotomy(open group).The intraoperative and postoperative situations of two groups were observed and compared.Results:The incision length,intraoperative blood loss,postoperative pain score,enterocinesia recovery time and postoperative hospital stay in laparoscpy group were better than those in open group(P 0.05 to P 0.01).The differences of operation time and postoperative complications in two groups were not statisticalty significant(P 0.05).Conclusions:The laparoseopic neoplasty in the treatment of gastroduodenal ulcer perforation is good effects,high safety,less trauma and fast recovery,which is worthy of clinical popularization and application.