盐酸替利定治疗中重度癌痛18例

    翟云芝, 郑荣生, 毕明宏

    翟云芝, 郑荣生, 毕明宏. 盐酸替利定治疗中重度癌痛18例[J]. 蚌埠医科大学学报, 2014, 38(2): 158-160.
    引用本文: 翟云芝, 郑荣生, 毕明宏. 盐酸替利定治疗中重度癌痛18例[J]. 蚌埠医科大学学报, 2014, 38(2): 158-160.
    Zhai Yunzhi, Zheng Rongsheng, Bi Minghong. Tilidine hydrochloride in the treatment of 33 patients with moderate to severe cancer pain[J]. Journal of Bengbu Medical University, 2014, 38(2): 158-160.
    Citation: Zhai Yunzhi, Zheng Rongsheng, Bi Minghong. Tilidine hydrochloride in the treatment of 33 patients with moderate to severe cancer pain[J]. Journal of Bengbu Medical University, 2014, 38(2): 158-160.

    盐酸替利定治疗中重度癌痛18例

    详细信息
      作者简介:

      翟云芝(1970- ),女,硕士研究生,副主任医师.

    Tilidine hydrochloride in the treatment of 33 patients with moderate to severe cancer pain

    • 摘要: 目的:评价盐酸替利定治疗中重度癌痛的疗效及安全性。方法:选择33例癌症患者,随机分为试验组18例和对照组15例。对照组用硫酸吗啡片20 mg,每日4次;试验组用盐酸替利定100 mg,每日4次,均连用5d。用数字评分法评估疼痛程度,记录疼痛变化及不良反应。同时在用药前及第6天做血常规、尿常规、肝肾功能和心电图检查。治疗结束后分别对症状、体征及实验室检查进行安全性和有效性评估。结果:2组服药前NRS评分差异无统计学意义(P0.05)。2组服药后第2~5天的NRS评分均较服药前明显降低(P0.01);服药后第2~5天,2组NRS评分差异均无统计学意义(P0.05)。癌痛有效率试验组为77.8%,对照组为73.3%,差异无统计学意义(P0.05);不良反应发生率分别为33.3%、40.0%,差异无统计学意义(P0.05)。结论:盐酸替利定和硫酸吗啡控制癌痛疗效和不良反应相似,可作为中重度癌痛的一线治疗。
      Abstract: Objective: To evaluate the safety and efficacy of tilidine hydrochloride in the treatment of moderate Objective: To severe cancer pain.Methods: Thirty-three cancer patients were randomly divided inObjective: To experimental group(18 cases) and control group(15 cases). Theexperimental group and control group were treated with 100 mg tilidine hydrochloride and 20 mg morphine sulfate 4 times daily for 5 days, espectively. The intensity of pain and adverse reactions were observed by numeral rating scale(NRS). The blood and urine routine, electrocardiogram and hepatic and nephritic function were detected at baseline and the sixth day. The signs and sympObjective: Toms and efficacy and safety of laboraObjective: Tory examination of two groups were evaluated at the end of treatment.Results: The NRS score of experimental group was 7. 28 1. 32 before tratment. On the No. 2nd,3rd,4 th and 5th days of treatment, the scores were 4. 94 1. 02,4. 00 0. 99,3. 67 0. 75 and 3. 22 0. 56, respectively. Compared with before treatment, the mean pain scores of two group were obviously improved after treatment,but the differences were not statistical significance(P > 0. 05). The effective and adverse reaction rates of the experimental group and control group were 77. 8% 73. 3% and 33. 3% 40%, respectively, the differences of two group had no statistical significance (P > 0. 05 ). Conclusions: The efficacy for controling cancer pain and adverse reactions of tilidine hydrochloride and morphine sulfate are similar,which can act as first-line treatment for moderate Objective: To severe cancer pain.
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    出版历程
    • 收稿日期:  2012-03-21
    • 刊出日期:  2014-02-14

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