Abstract: Objective: To compare the effects of pectin bismuth triple and quadruple therapy in the treatment of Helicobacter pylori (Hp) positive gastric ulcer and duodenal ulcer. Methods: One hundred and twenty-five cases of Hp-positive gastric ulcer and duodenal ulcer were confirmed by electronic endoscopy and rapid urease test. The triple therapy group received bismuth pectin 0. 2 g，3 times a day，clarithromycin 0. 5 g plus metronidazole 0. 4 g twice a day for two weeks; the quadruple therapy group were administered bismuth pectin 0. 2 g，3 times a day， clarithromycin 0. 5 g plus metronid azole 0. 4 g and rabeprazole azole 20 mg twice a day for one week. Four weeks later， the eradication rate of the Hp and the healing rate of the peptic ulcer were evaluated according Objective: To the results of the peated electronic endoscopy and the rapid urease test. Results: One hundred and twenty-five cases were followed up. The Objective: Total effective rate of the quadruple therapy was higher than that of the triple therapy(P ＜ 0. 05) ; the quadruple therapy was superior Objective: To the triple therapy in relieving the pain(P ＜ 0. 01) ; there was less incidence of adverse reactions in the quadruple therapy group than the triple therapy group (P ＜ 0. 05) ; there was no statistical difference in the Hp eradication rate between the quadruple therapy group and the triple therapy group(P ＞ 0. 05). Conclusions: The quadruple therapy containing rabeprazole is superior Objective: To the triple therapy in the time of pain relief，ulcer healing and incidence of adverse reactions in treatment of Hp-positive gastric ulcer and duodenal ulcer.