The effect of ambroxol hydrochloride combined with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome
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摘要: 目的：探讨盐酸氨溴索联合鼻塞式持续气道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的临床效果。方法：130例NRDS患儿随机分为观察组66例和对照组64例,对照组给予NCPAP等综合治疗,观察组在对照组基础上静脉注射盐酸氨溴索7.5 mg/kg,每6 h 1次,连用7 d。观察2组NCPAP时间、机械通气使用率、机械通气时间、氧疗时间、氧合指数(OI)及住院费用。结果:观察组NCPAP时间、机械通气时间及氧疗时间均明显短于对照组,治疗后24 h、36 h及48 h的OI均高于对照组,住院费用明显低于对照组(P0.01);但2组治疗后12 h的OI、机械通气使用率和病死率差异均无统计学意义(P0.05)。结论：盐酸氨溴索联合NCPAP较单用NCPAP治疗NRDS疗效好、安全。
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关键词:
- 呼吸窘迫综合征 /
- 盐酸氨溴索 /
- 鼻塞式持续气道正压通气 /
- 新生儿
Abstract: Objective: To investigate the clinical effects and safety of ambroxol hydrochloride combined with nasal continuous positive airway pressure(NCPAP) in the treatment of neonatal respiraObjective: Tory distress syndrome (NRDS). Methods: One hundred and thirty neonates with NRDS were randomly divided inObjective: To observation group(66 cases) and cont〗rol group(64 cases). The control group and observation group were treated with NCPAP and NCPAP combined with 7. 5 mg /kg of ambroxol hydrochloride every 6 hours for 7 days by intravenous injection， respectively. The time of NCPAP，mechanical ventilation and oxygen therapy， the use of mechanical ventilation，oxygen index(OI) and hospitalization expense of two groups were observed. Results: The time of NCPAP，mechanical ventilation and oxygen therapy of observation group were significantly shorter than those in the control group， the OI of observation group was significantly higher than that in the control group at 24， 36 and 48 hours after treatment， the hospitalization expense of observation group was significantly less than that in the control group(P ＜ 0. 01). The differences of the OI，use of mechanical ventilation and mortality of two groups were not statistically significant(P ＞ 0. 05). Conclusions: Ambroxol hydrochloride combined with NCPAP for treating NRDS is safer and better than NCPAP therapy -
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