Abstract: Objective: To investigate the correlations of quality of life with anxiety and depression in patients with leukemia.Methods: The quality of life,anxiety and depression in 56 patients with leukemia were investigated using the core quality of life questionnaire and hospital anxiety and depression scale.Results: Among 56 leukemia patients,20 cases with anxiety and 18 cases with depression were found.The scores of general health status,emotional and cognitive function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05),but the scores of fatigue,pain and loss of appetite in positive anxiety patients were significantly high(P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The scores of general health status,and role,emotional,cognitive and social function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05 to P<0.01),but the scores of fatigue,pain,shortness of breath,insomnia,loss of appetite and depression in positive anxiety patients were significantly high(P<0.05 to P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The anxiety and depression in leukemia patients were negatively correlated to the general health status,and role,emotional,cognitive and social function(P<0.05 to P<0.01),and positively correlated to fatigue,pain,shortness of breath,insomnia and appetite loss(P<0.05 to P<0.01),and uncorrelated to other factors(P>0.05).Conclusions: The incidences of anxiety and depression in patients with leukemia are high and their overall qualities of life are low,which can provide a reference in improving the quality of life of patient by improving their anxiety and depression.