Abstract: Objective: To evaluate the effects of different concentrations of lidocaine on the hemodynamics of patients radical resection of esophageal cancer.Methods: Fifty-four ASAⅠ-Ⅱpatients were randomly divided into epidural normal saline(NS) group,epidural 1% lidocaine(Lido) group and epidural 2% Lido group,with 18 cases in each group.Anesthesia was induced and maintained with epidural infusion of Lido or NS at 7 ml/h.The baseline value,blood pressure(BP),heart rate(HR) of the patients were recorded before and during the operation.Results: During the operation,NS group showed a higher BT and HR(P<0.01),2% Lido group an over-decrease in BP and lower HR(P>0.05),and 1% Lido group a comparatively stable BP and HR.Conclusions: General anesthesia combined with local anesthesia is effective and safe in radical resection of esophaged cancer.