Abstract: Objective:To investigate the correlation of the levels of plasma homocysteine(Hcy) and ischemic stroke，and the significance of vitamin B12 combined with folie acid in the treatment of ischemic stroke． Methods:The levels of plasma Hcy of 62 patients with ischemic stroke(stroke group) and 30 elderly patients with digestive system disease and without cerebrovascular disease (control group) were detected． Sixty-two patients with ischemic stroke were randomly divided into the treatment group and convention group，the convention group and treatment group were treated with conventional method and conventional method combined with vitamin B12 and folie acid，respectively． The levels of plasma Hcy of patients with ischemic stroke were detected after treatment again． Results: The levels of plasma Hcy in stroke group were significantly higher than that in control group(P 0． 01)． The levels of plasma Hcy in treatment group treated with vitamin B12 and folie acid were obviously decreased(P 0． 01)，the treatment effect of which was obviously better than that of control group(P 0． 01)． Conclusions:There is a positive correlation between the plasma Hcy level and ischemic stroke． The treatment with vitamin B12 combined with folie acid can decrease the plasma Hcy level，which plays certain role on preventing and treating ischemic stroke．