Abstract: Objective:To explore the diagnosis and treatment of postsurgical gastroplegia syndrome(PGS) of esophageal cancer． Methods:The clinical data of PGS in 23 cases with esophageal cancer were retrospectively analyzed． Results:The mean disease time of gastroplegia syndrome was 7 to 9 months after operation，the main symptoms were epigastric pain，nausea and vomiting． All patients were diagnosed with PGS by upper gastrointestinal contrast，ultrasound and electronic gastroscope Twenty-three patients were treated with gastrointestinal decompression，nutritional support，maintaining water electrolyte metabolism balance，promoting gastrointestinal peristalsis and reducing stomach wall edema． The stomach function recovery of 18 cases，3 cases and 1 case were within 3 weeks，4 weeks and 8 weeks，respectively． One case cured by stomach-jejunum anastomosis when it was not improved by conservative treatment for 3 months． Conclusions:The main diagnosis basis of PGS are its symptoms and the resuts of upper gastrointestinal contrast， ultrasound and electronic gastroscope． The effects of nonoperative treatment on gastroplegia syndrome are good．