Abstract: Objective:To explore the clinical features and treatment experience of severe hand-foot-mouth disease in children． Methods:The clinical data of 155 children with severe hand-foot-mouth disease were retrospectively analyzed． All patients were treated with intravenous gamma globulin，methylprednisolone based on anti-infection and symptomatic treatment，and reducing intracranial pressure，improving circulation and myocardium and supporting respiratory according to patient' s condition． Results: Amony 155 patients，the severe hand-foot-mouth disease tended to occur in children less than 3 years old(91． 6%)，1 to 2 years old children accounted for 60． 6%． The ratio of boy to girl was 1． 5 to 1，the rural children were 121 cases(72． 2%)． The skittishness and rash in all patients were found． The fever in 147 cases，lethargy and poor spirit in 110 cases，limb jitter in 32 cases，nausea and vomiting in 14 cases，cold sweat in 3 cases，WBC rising in 75 cases，creatine kinase isoenzyme rising in 68 cases，blood sugar rising in 45 cases，C reactive protein rising in 37 cases，high blood pressure rising 33 cases and heart rate increasing in 16 cases were found． The abnormal cerebrospinal fluid in 148 cases was found by examination． One hundred and fifty-three patients including 1 case with acute flaccid paralysis were cured，2 cases died． Conclusions:The severe hand-foot-mouth disease often occurs in children less than 3 years old，the blood pressure，blood sugar，heart rate of vital signs in children with fever，lethargy and shock psychiatric symptoms should be closely observed． The early diagnosis and intervention are the key to reduce the mortality rate and sequela and improve the prognosis．