Abstract: Objective: To investigate the clinical features of cytomegalovirus(CMV) pneumonia and the therapeutic effect of ganciclovir(GCV)in treatment of the disease.Methods: The clinical features of 46 children with CMV pneumonia were analyzed retrospectively.The clinical symptom,sign,ALT,chest radiographs,and the size of liver and spleen were detected before and after GCV therapy.Results: Cough was the most common symptom of CMV pneumonia in infants(82.61%).CMV pneumonia cases showed interstitial pneumonia(80.43%).Children with CMV pneumonia more often had liver and spleen involvement.After 14 days of GVC(from 5 to 7.5 mg/kg Q12h intravenous infusion) therapy,the clinical symptom,sign,chest radiographs,enlarged liver and spleen,and liver function improved.No obvious adverse effect was observed during the therapy.Conclusions: CMV pneumonia should be considered in infants with cough and complications.GCV is safe and effective in treatment of CMV infection.