Abstract: Objective: To observe the therapeutic effects of Yangxue Qingnao granule with long course treatment on chronic cerebral circulation insufficiency(CCCI).Methods: One hundred and nine patients who were diagnosed CCCI took Yangxue Qingnao granule(4 g,tid) orally,consecutively.The changes of clinical symptoms were observed after 4,8 and 12 weeks.The changes of blood rheology and transcranial doppler(TCD) examination were also observed after 4,8 and 12 weeks.Results: Effective power of patients who had take Yangxue Qingnao granule for 8 weeks was higher than who took it for 4 weeks(P<0.01),and the effective power of patients taking the medicine for 12 weeks was higher than the others(P<0.01).Indexes of blood rheology and TCD examination after 12 weeks were improved.Conclusions: Long course treatment with Yangxue Qingnao granule on CCCI is safely and reliable.