Abstract: Objective:To investigate the expression and clinical significance of lung resistance related protein (LRP) and multidrug resistance associated protein (MRP) in lung cancer.Methods:Sixty two cases of lung cancer were detected of the presence of LRP and MRP by immunohistochemical analysis.Results:The expression of LRP and MRP,in lung cancer was 61.3% and 70.0% respectively,and their common positive expression was 51.6%.The expreesion of LRP and MRP had no significant diffrerence in the clinicopathological variables including age,sex,pathology type,differentiation degree or TNM stage (P>0.05).In addition,LRP had no correlation with MRP (P>0.05).Conclusions:The expression of LRP and MRP is related with lung cancer's intrinsic drug resistance,but not obviously coorelated with the clinicopathological characteristics.There is no correlation between LRP and MRP.