SGSM3 rs56228771与中国汉族人群结直肠癌遗传易感性的关联

张舒龙; 朱勇; 李仕青; 蔡舒

SGSM3 rs56228771与中国汉族人群结直肠癌遗传易感性的关联

The correlation of SGSM3 rs56228771 polymorphisms and susceptibility of colorectal cancer in Han people

摘要

摘要: 目的：探讨小G蛋白信号调制因子3基因（SGSM3） 4碱基插入/缺失多态rs56228771与中国汉族人群结直肠癌遗传易感性之间的相关性。方法：采用非变性聚丙烯酰胺凝胶电泳方法检测339例汉族结直肠癌患者和319名健康人（对照组）的SGSM3 rs56228771多态性的分布频率，以非条件性logistic回归模型分别对年龄、性别、吸烟及饮酒状况进行校正后计算优势比（OR）及95%置信区间（CI）。结果：结直肠癌组SGSM3基因型（I/I、I/D、D/D）分布频率分别为2.36%、24.78%和72.86%，对照组分别为4.08%、33.86%和62.07%，2组的频率分布差异有统计学意义（P<0.05）。携带SGSM3 I/I基因型的个体较携带D/D基因型的个体患结直肠癌的风险降低（OR=0.49；95%CI 0.20~1.21；P<0.05）。等位基因分析表明，携带SGSM3 I基因的个体较携带D基因的个体患结直肠癌的风险降低（OR=0.65；95%CI 0.49~0.87；P<0.01）。结论：SGSM3 rs56228771位点多态性与中国汉族人群结直肠癌易感性具有相关性。

Abstract: Objective: To explore the correlation of SGSM3 rs56228771 polymorphisms and susceptibility of colorectal cancer in Han people.Methods: The distribution frequencies of SGSM3 rs56228771 in 339 Han patients with colorectal cancer(colorectal neoplasm group) and 319 healthy people were detected using non-denaturing PAGE.The odds ratio(OR) and 95% confidence intervals(CI) of age,sex,smoking and drinking status after adjustment were calculated using unconditional logistic regression analysis.Results: The frequencies of SGSM3 I/I,I/D and D/D genotypes in colorectal cancer group and control group were 2.36%,24.78% and 72.86%,and 4.08%,33.86% and 62.07%,respectively,the differences of whose were statistically significant(P<0.05).The risk of colorectal cancer in cases with SGSM3 I/I genotype was lower than that in cases with D/D genotype(OR=0.62,95%CI 0.20 to 1.21,P<0.05).The risk of colorectal cancer in cases with SGSM3 I gene was lower than that in cases with D gene(OR=0.49,95%CI 0.49 to 0.87,P<0.01).Conclusions: The SGSM3 rs56228771 polymorphism is directly related to the susceptibility of colorectal cancer in Han people.

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