Abstract: Objective: To observe the effect of selective artery interventional therapy with octreotide on severe acute pancreatitis(SAP).Methods: Sixty-three SAP patients were divided into control group(36 cases) and treatment group(27 cases).The control group received only the routine therapy,while the the treatment group received interventional therapy in addition to the routine therapy.A catheter was placed to the pancreas feeding artery according to CT check and digital subtraction angiography(DSA) device,and octreotide 0.1 mg was supplied every 6 h for 3 to 7 days.The curative effects of the two groups were compared.Results: The blood amylase reduced more quickly in the treatment group than in control group.The gastrointestinal decompression was significantly different between the two groups(P<0.01) and the treatment time was shortened obviously in the treatment group(P<0.01).The complication incidence rate,change surgery rate and fatality rate were 14.81%,3.70% and 0.00%,in the treatment group,and 44.44%,22.22% and 16.67% in the control group,respectively.Conclusions: The curative effect of interventional therapy using octreotide is much better than the routine therapy for SAP.