Abstract: Objective:To investigate the effects of the cross-growth titanium plate on fixing the type IV Salter-Harries epiphyses injury in animal experiment.Methods:Twenty-four healthy goats with the age of 6 to 7 weeks were randomly divided into the blank group,kirschner group and across-growth titanium plate group(8 goats each group).The animal models of the kirschner group and across-growth titanium plate group were established by kirschner drilling the distal epiphyses in two sides of humerus,which was fixed using across-growth titanium plate and kirschner,respectively.The biomechanical testing of 4 goats from each group after 8 or 12 weeks of operation were implemented and compared.Results:After 8 and 12 weeks of operation,the differences of the yield strength,maximum load,maximum elastic modulus and breaking point between blank group and across-growth titanium plate group were not statistically significant(P >0.05),and each indicator in the two groups were better than those in kirschner group(P<0.01).Conclusions:The treatment of type Ⅳ Salter-Harries epiphyses injury with cross-growth titanium plate can effectively meet the fixation strength of the bio-mechanics,which can provide a relatively stable setting to accelerate the repair process of the epiphyses injury.