格列美脲、二甲双胍治疗代谢综合征的疗效观察

李昉; 汤广锋; 唐同翠; 杨玉红; 张志民

格列美脲、二甲双胍治疗代谢综合征的疗效观察

Glinepiride and metformin in the treatment of metabolism syndrome

摘要

摘要: 目的: 观察格列美脲、二甲双胍治疗代谢综合征(MS)的疗效。方法: 将68例代谢综合征患者随机分成两组,分别采用格列美脲、二甲双胍治疗。观察两组治疗前后空腹血糖(FBG)、餐后血糖(PBG)、糖化血红蛋白(HbA1C)、甘油三脂(TG)、空腹胰岛素(FIn)、体重指数(BMI)的变化。结果: 两组治疗后FBG、PBG、HbA1C、FIn均较治疗前下降(P<0.01),但格列美脲组FIn下降程度高于二甲双胍组(P<0.01)。两组治疗后TG及BMI均较治疗前下降(P<0.01)。结论: 格列美脲和二甲双胍均能改善代谢综合征患者的糖代谢、脂代谢,而格列美脲改善胰岛素抵抗,增加胰岛素敏感性较二甲双胍作用强。

Abstract: Objective: To evaluate the effect of glimepiride and metformin therapy on metabolic syndrome (MS).Methods: Sixty-eight patients with MS were randomly assigned to receive glimepiride or metformin.The fasting blood glucose (FBG), postprandial blood glucose (PBG), glycosylated hemoglobin (HbA1C), triglycerides (TG), fasting insulin levels (FIn) and the values of body mass index (BMI) of the two groups were compared before and after treatment.Results: FBG, PBG, HbA1C and FIn decreased significantly in the two groups (P<0.01), but FIn decreased more obviously in the glimepiride group (P<0.01).TG level and BMI decreased significantly in the two groups (P<0.01).Conclusions: Both glimepiride and metformin can improve the glucose metabolism and lipid metabolism.Glimepiride is more effective than metformine in improveing IR and insulin sensitiviry.

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