Abstract: Objective: To explore the role of administration of dopamine and phentolamine dropping in vein persistently and slowly in treatment of premature infants in early period.Methods: Eighty-three live birth premature infants with high risk of latent shock were randomly divided into early intervention group(42 cases) and control group(41 cases).For the control group,the infants were kept warm,protect from infection and respiration pause,and dealt with their symptoms.For the intervention group,dopamine 0.5 mg·kg^-1·time^-1,phentolamine 0.25 mg·kg^-1·time^-1 were added.Dopamine 5-10 μg·kg^-1·min^-1 with 5% glucose were administered to drop in vein q8h or q12h persistently and slowly.The scleroderma incidence rate and the death rate of the premature infants of the two groups were observed.Results: There were 7 fatality cases in the early intervention group,but 15 fatality cases in the contrast group.The difference was significant(P<0.05).Scleroderma incidence rate in early intervention group was 28.57%,while it was 60.98% in the contrast group.There were distinct differences between the two groups(P<0.01)Conclusions: Dopamine and phentolamine are effective in preventing infant scleredema and reducing the fatality of premature infants while their acral temperature and peripheral circulation should be observed during the administration.