李静. 影响急性白血病初治诱导缓解因素分析[J]. 蚌埠医学院学报, 2004, 29(3): 234-236.
    引用本文: 李静. 影响急性白血病初治诱导缓解因素分析[J]. 蚌埠医学院学报, 2004, 29(3): 234-236.
    LI Jing. Factors affecting first induce remission for acute leukemia[J]. Journal of Bengbu Medical College, 2004, 29(3): 234-236.
    Citation: LI Jing. Factors affecting first induce remission for acute leukemia[J]. Journal of Bengbu Medical College, 2004, 29(3): 234-236.

    影响急性白血病初治诱导缓解因素分析

    Factors affecting first induce remission for acute leukemia

    • 摘要: 目的: 探讨影响急性白血病初治诱导缓解的因素。方法: 39例急性白血病(AL)按初治诱导缓解成功与否分为两组,分析AL患者的年龄、性别、疾病的FAB分型、化疗前外周血情况、血清乳酸脱氢酶、化疗方案及药物剂量的选择等指标。结果: 12例两次诱导缓解后完全缓解(CR),9例首次化疗后骨髓中原始幼稚细胞指数下降>50%(缓解组),18例未缓解(难治组)。两组相比,难治组高龄,FAB中属急性非淋巴细胞白血病(急非淋),化疗前外周血白细胞比例高,血清乳酸脱氢酶水平高,原发耐药比例高。而在急非淋中"MEA"方案的缓解率高于"DA"、"HA"方案,急性淋巴细胞白血病中"L-CNDP"的缓解率较其他方案高。结论: AL患者年龄、FAB分型、化疗前瘤细胞负荷、化疗方案的选择是影响急性白血病初次诱导缓解的因素。而早期骨髓抑制继发的革兰阴性菌感染败血症是AL早期死亡的主要原因。

       

      Abstract: Objective: To discuss the factors influencing first induce remission for acute leukemia.Methods: Thirty nine patients with acute leukemia were divided into two groups according to whether the first induce remission was successful or not.The inderes of the patients,such as age,sex,type of FAB,amount of the blood cell before drug therapy,concentration of LDH in serum,as well as the projection of the drug therapy and the dose of medicine were analysed.Results: Complete remission occurred in 12 patients after twice induce remission;9 patients' index of original cell in marrow declined,and 18 patients failed to response.Senior,ANLL,high amount of blood cell before durg therapy or high concentration of LDH in serum were the factors leading to difficult remission.Complete remission rate by MEA was higher than that by DA or HA for ANLL.Complete remission rate by L CVDP was high than that by other projections for ALL.Conclusions: Factors affecting first induce remisson for acute leukemia include age,sex,type of FAB,amount of the tumor cell before durg therapy and projection of the drug therapy.

       

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