Abstract: Objective: To observe the clinical features of the newborns with aspiration pneumonia and to investigate the effect of phentolamine in treatment of the disease.Methods: Fifty-three newborns with aspiration pneumonia were randomly divided into phentolamine group(32 cases) and routine group(21 cases).In addition to the routine therapy of antibiotic,oxygen and support treatment,the test group were added phentolamine 2-5 μg·kg^-1·min^-1 twice a day,two hours at a time and the progress of the disease was observed.Results: The total effective rates were 93.7% and 61.9% in the phentolamine group and the routine group respectively.The difference between the two groups was remarkable(P<0.05);the time of ecphysesis and the hospital stay in the phentolamine group were significantly less than that of the routine group(P<0.001).Conclusions: The application of Phentolamine based on the routine treatment can obviously improve the clinical symptoms and shorten the hospital stay.It is safe and effective.