昝丽娜, 李玉云, 谢扬虎, 程佩萍, 江杨帆, 吴俊英. 再生障碍性贫血患者血浆IL-3和IL-8水平的检测[J]. 蚌埠医学院学报, 2011, 36(3): 293-295.
    引用本文: 昝丽娜, 李玉云, 谢扬虎, 程佩萍, 江杨帆, 吴俊英. 再生障碍性贫血患者血浆IL-3和IL-8水平的检测[J]. 蚌埠医学院学报, 2011, 36(3): 293-295.
    ZAN Li-na, LI Yu-yun, XIE Yang-hu, CHENG Pei-ping, JIANG Yang-fan, WU Jun-ying. Detection of interleukin-3 and interleukin-8 levels in plasma of aplastic anemia patients[J]. Journal of Bengbu Medical College, 2011, 36(3): 293-295.
    Citation: ZAN Li-na, LI Yu-yun, XIE Yang-hu, CHENG Pei-ping, JIANG Yang-fan, WU Jun-ying. Detection of interleukin-3 and interleukin-8 levels in plasma of aplastic anemia patients[J]. Journal of Bengbu Medical College, 2011, 36(3): 293-295.

    再生障碍性贫血患者血浆IL-3和IL-8水平的检测

    Detection of interleukin-3 and interleukin-8 levels in plasma of aplastic anemia patients

    • 摘要: 目的: 研究白细胞介素3(IL-3)和IL-8在再生障碍性贫血(aplastic anemia,AA)发病机制中的变化及临床意义。方法: 采用双抗体酶联免疫吸附试验检测30例AA患者(AA组,其中PIG-A基因突变组14例,无PIG-A基因突变组16例)和20名健康志愿者(对照组)血浆中IL-3和IL-8的水平。结果: AA患者血浆中IL-3水平与对照组差异无统计学意义(P>0.05);无PIG-A基因突变组AA患者,其血浆IL-8的水平均明显高于对照组和有PIG-A基因突变组(P<0.01);PIG-A基因突变组血浆IL-8水平与对照组差异无统计学意义(P>0.05)。对AA组IL-3和IL-8水平作相关分析,显示二者无直线相关关系(P>0.05)。结论: AA患者存在细胞免疫功能紊乱,IL-8的分泌异常可能在AA的发病机制中起到一定作用,特别是IL-8的过高分泌可能与AA的发病有着密切的联系。

       

      Abstract: Objective: To observe changes of interleukin-3 (IL-3) and interleukin-8 (IL-8) levels and discuss its significance in pathogenesis of aplastic anemia (AA). Methods: The method of ELISA was used to detect IL-3 and IL-8 levels in plasma of 30 AA patients and 10 normal volunteers. Results: There was no significant difference of plasma IL-3 levels between the AA patients and controls (P>0.05); Compared with groups of the normal controls and the patients with PIG-A gene mutation,the levels of plasma IL-8 significantly increased in the group of AA patients without PIG-A gene mutation (P<0.01); There was no significant difference of plasma IL-8 levels between the group of AA patients with PIG-A mutation and the normal controls (P>0.05). Conclusions: There are cellular immune dysfunction in patients with AA. Abnormal levels of IL-8 might be involved in the pathogenesis of AA and high level of IL-8 may closely linked to the occurrence of AA.

       

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