Abstract: Objective: To evaluate diagnosis and treatment methods of endometrial atypical proliferation.Methods: The clinical data of 28 cases of endometrial atypical proliferation were retrospectively reviewed.Results: Three cases received drug therapy,1 case was under treatment and 2 cases were proved to have benign lesion by diagnostic curettage.Seventeen cases received surgical therapy and no relapse was detected in the follow-up,excepting for 4 patients who were not in the city and were not followed up.Conclusions: Precancerous lesion and early endometrial carcinoma can be detected through mass screening,which will enable the patients to receive treatment in the early stage and avoid endometrial carcinoma.