Abstract: Objective: To explore the diagnosis and treatment of malignant gastric stromal tumors.Methods: The clinical data of 20 cases of malignant gastric stromal tumor having received surgical management were reviewed.Fourteen cases underwent radical subtotal or total gastrectomy,5 local resections,1 parative total gastrectomy and 5 combined resection of other viscera.Results: Most of the patients with malignant gastric stromal tumors were adults.The patients ≥ 50 years of age accounted for 70%(14/20).Gastrointestinal hemorrhage,anemia and pain were the main clinical manifestations.There were no perioperative death and main postoperative complication,all cases healed.Conclusions: Endoscopy and imaging examination are the main methods to detect malignant gastric stromal tumors.Preoperation diagnosis is still difficult.Surgical resection is the main method for pathologic diagnosis and treatment.Sometimes combined resection of other viscera is necessary to ensure the tumor completely resected,which is of great value to prevent recurrence of the tumor.