地尔硫用于颈丛阻滞下甲状腺手术对心血管反应的影响

张曙; 段思源; 张树强

地尔硫用于颈丛阻滞下甲状腺手术对心血管反应的影响

Effects of diltiazem on cardiovascular responses during thyroidectomy with cervical plexus block

摘要

摘要: 目的: 观察钙离子阻滞剂地尔硫静脉滴注(静滴)对颈丛阻滞下甲状腺手术患者血压和心率的影响。方法: 40例单侧甲状腺择期手术患者,随机分为A、B两组。行颈丛阻滞后15min,A组予5%葡萄糖注射液静滴,B组使用地尔硫10 mg于1min内静脉注射,继以50 mg+5%葡萄糖注射液,以5-8μg·min^-1·kg^-1持续静滴。记录基础值、颈丛阻滞后5min、15min、30min、60min及术毕时间点的收缩压(SBP)、舒张压(DBP)、心率(HR)。结果: 两组在颈丛阻滞后的5min、15min的血压和心率明显升高(P<0.01)。B组在使用地尔硫15min后的血压和心率明显下降,未见不良反应。结论: 颈丛阻滞下甲状腺手术静滴地尔硫可以明显抑制心血管不良反应,用药安全,值得临床推广。

Abstract: Objective: To observe the effects of the calcium channel blocker diltiazem on the cardiovascular system during operation of thyroidectomy with cervical plexus block.Methods: Forty patients undergoing selected unilateral thyroidectomy were randomly divided into group A(n=20) and group B(n=20).Fifteen minutes after cervical plexus blockade,group B were injected with diltiazem at the dosage of 5 to 8 μg·min^-1·kg^-1.SBP,DBP and HR were recorded before anesthesia,5 minutes,15 minutes,30 minutes,60 minutes after cervical plexus blockade and at the end of surgery(T₆).Results: In both group A and B,SBP,DBP and HR were significantly increased in 5 minutes and 15 minutes after cervical plexus blockade(P<0.01),while those were significantly decreased in 15 minutes after the injection of diltiazem.No adverse reaction was observed.Conclusions: Injection with diltiazem can significantly inhibit the reaction of cardiovascular system during operation of thyroidectomy with cervical plexus block.It can be used safely and worth popularizing.

HTML全文

参考文献(0)

施引文献

资源附件(0)