动态心电图检查及血清IMA、Gal-3对急性心肌梗死的评价及预后相关分析

    Evaluation and prognostic correlation analysis of dynamic electrocardiogram and serum IMA and Gal-3 levels in acute myocardial infarction

    • 摘要:
      目的: 探讨动态心电图检查及血清缺血修饰白蛋白(IMA)、半乳糖凝集素3(Gal-3)对急性心肌梗死(AMI)的评价及预后相关分析。
      方法: 选取102例急性心肌梗死病人作为研究对象,均予以经皮冠状动脉介入术(PCI)治疗,术后随访1年,以是否发生不良心血管事件(MACE)分为预后不良组(n = 35)和预后良好组(n = 67),同期选取51例健康体检者为健康对照组;比较3组动态心电图参数QT间期离散度(QTd)、经心率校正的QT离散度(QTcd)、NN间期标准差(SDNN)、震荡起始(TO)、震荡斜率(TS)、IMA、Gal-3。
      结果: 预后不良组的SDNN、TS低于预后良好组和健康对照组,而TO高于预后良好组和健康对照组(P < 0.05~P < 0.01)。预后不良组的IMA、Gal-3均高于预后良好组和健康对照组(P < 0.01)。logistic回归分析显示,SDNN、TS下降和TO、IMA、Gal-3升高是AMI病人预后不良的独立危险因素(P < 0.05~P < 0.01)。ROC曲线分析显示, SDNN、TO、TS、IMA、Gal-3及三项联合预测AMI病人预后不良的AUC值分别为(0.728、0.748、0.743、0.773、0.779、0.983,P < 0.01)。
      结论: 动态心电图参数及血清IMA、Gal-3在急性心肌梗死病人中呈异常表达趋势,检测其变化有利于为预后评估提供指导。

       

      Abstract:
      Objective To explore the evaluation of Holter and serum ischemia modified albumin (IMA) and galectin-3 (Gal-3) on acute myocardial infarction (AMI) and the correlation analysis of prognosis.
      Methods A total of 102 patients with acute myocardial infarction were selected as the research objects, all of whom were treated with percutaneous coronary intervention (PCI), and were followed up for 1 year. They were divided into the poor prognosis group (n = 35) and the good prognosis group (n = 67) according to the occurrence of adverse cardiovascular events (MACE). Fifty-one healthy people were selected as the healthy control group at the same time; The Holter parameters QT interval dispersion (QTd), QT dispersion corrected by heart rate (QTcd), standard deviation of NN interval (SDNN), onset of oscillation (to), slope of oscillation (TS), IMA, Gal-3 were compared among the three groups.
      Results The SDNN and TS of the poor prognosis group were lower than those of the good prognosis group and the healthy control group, while the TO was higher than that of the good prognosis group and the healthy control group (P < 0.05 ~ P < 0.01). IMA and Gal-3 in the poor prognosis group were higher than those in the good prognosis group and the healthy control group (P < 0.01). Logistic regression analysis showed that SDNN, TS decreased and TO, IMA, Gal-3 increased were independent risk factors for poor prognosis of AMI patients (P < 0.05 ~ P <0.01). ROC curve analysis showed that, The AUC values of SDNN, to, TS, IMA, Gal-3 and their combination in predicting the poor prognosis of AMI patients were (0.728, 0.748, 0.743, 0.773, 0.779, 0.983, P < 0.01).
      Conclusion The dynamic electrocardiogram parameters and serum IMA, Gal-3 showed an abnormal expression trend in patients with acute myocardial infarction. Detection of their changes is conducive to provide guidance for prognosis evaluation.

       

    /

    返回文章
    返回