Abstract: Objective: To compare the clinical effects between furbiprofen and nefopam in patient-controlled intravenous analgesia(PCIA).Methods: Ninety patients with selective general anesthesia were randomly divided into three groups:Group A(n=30) was given 100 ml mixture solution of furbiprofen 100 mg,fentanyl 0.35mg and 0.9% NaCl;Group B(n=30) was given 100 ml mixture solution of furbiprofen 100 mg and 0.9% NaCl;Group C(n=30) was given 100 ml mixture solution of nefopam 100 mg,fentanl 0.35 mg and 0.9% NaCl.The patients in Group A and Group B were injected furbiprofen intravenously 50mg immediately after intubation,while Group C patients were injected nefopam 20 mg intravenously 10 minutes before the end of operation.All the patients were injected ondansetron 4 mg intravenously after operation.VAS and associated bad responses were observed 2 hours,4 hours,8 hours,16 hours,24 hours,and 36 hours after operation.The number of PCIA within 36 hours was recorded and the satisfaction of PCIA was investigated.Results: All the patients were smooth after operation.VAS at every time point and the number of PCIA in Group B and Group C were significantly higher than those in Group A(P<0.01).There was no significant difference between Group B and Group C.Throat pain and bad responses of spirit discomfort in Group C were significantly higher than those in Group A and Group B(P<0.01) and there was no significant difference between Group A and Group B(P>0.05);The satisfactory degree in Group A was significantly higher than Group B and Group C.Conclusions: Both furbiprofen and nefopam can be used in PICA.The effect of furbiprofen is much more satisfactory than fentanyl with the same small amount and the bad responses are much less.