Abstract: Objective: To investigate the expression of E-cadherin(ECD) and its clinical value in predicting the prognosis of laryngeal carcinoma.Methods: The expression of ECD was determined by immunohistochemistry with EnVision two-step method on tissue microarray slides in 79 cases of laryngeal carcinoma tissues;the relationship between the pathological features and the prognosis was analyzed.Results: Negative expression of ECD was detected in 11 cases of the tissue(13.3%);The ECD expression had no statistical differences between the clinical and the pathological features of the patients with the laryngeal carcinoma(P>0.05).The positive rates of ECD were 76.74% and 94.44% in the dead patients and the survival ones respectively;the difference was statistically significant(P<0.05).Conclusions: The ECD expression may be of great value in predicting the prognosis of patients with the laryngeal carcinoma.