Objective To investigate whether there is a correlation between the level of residual cholesterol (RC) in blood and the development of large artery atherosclerotic ischemic stroke (LAA-IS).

Methods A total of 156 patients with LAA-IS were selected as the observation group, and 156 healthy medical check-ups in the same period were selected as the control group. General data and biochemical indexes were collected between the 2 groups, and the effects of RC levels on LAA-IS were analyzed using logistic regression analysis, Spearman correlation analysis, and ROC curves.

Results Compared with the control group, the observation group had higher levels of hypertension, body mass index, triacylglycerol, low-density lipoprotein cholesterol, RC, and high homocysteine, while the levels of high-density lipoprotein cholesterol and apolipoprotein A were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Logistic regression analysis showed that high blood pressure, elevated RC, and elevated high homocysteine might be the risk factors of LAA-IS, and the elevated apolipoprotein A (ApoA) might be a protective factor (P ＜ 0.05). ROC curve analysis showed that the area under the curve of LAA-IS assessed by RC was 0.853, with a sensitivity of 66.7% and a specificity of 94.2%.

Conclusion RC is an independent risk factor for LAA-IS and can predict LAA-IS.