Abstract: Objective: To observe the effect,adverse reaction and cytoimmunity function of ginsenoside Rg3 capsules combined with FOLFOX4 regimen in treatment of advanced colon cancer.Methods: Sixty-seven patients were randomly divided into two groups.Group A(32 cases) received FOLFOX4 regimen only,and Group B(35 cases) were treated with ginsenoside Rg3 capsules plus FOLFOX4 regimen.Results: The response rate was 40.6% in group A and 45.7% in group B(P>0.05).A lower response rate of leucopenia occurred in group B compared with that in group A(P<0.05-P<0.01).The difference was significant in the elevation of T lymphocyte subset and life quality between the two groups.Conclusions: Ginsenoside Rg3 capsules can decrease the side effects of chemotherapy and improve the immunity and life quality of the patients with advanced colon cancer.