大剂量顺铂和氟尿嘧啶/亚叶酸钙合甲羟孕酮治疗晚期胃肠腺癌

High dose of cisplatin combined with 5-fluorouracil/leucovorin plus medroxypro-gesterone acetate in treatment of advanced castric and colorectal adenocarcinoma

摘要: 目的: 观察大剂量顺铂(HD-DDP)、亚叶酸钙(CF)、氟尿嘧啶(5-Fu)并用甲羟孕酮(MPA)治疗晚期胃肠道腺癌的效果及不良反应。方法: 应用HD-DDP加5-Fu/CF加MPA治疗晚期胃肠腺癌37例。结果: CR 0例,PR 15例,CR加PR 40.5%;不良反应主要是恶心、呕吐、Ⅱ度以上占24.3%,只有2例BUN升高。结论: HD-DDP加5-Fu/CF加MPA方案治疗晚期胃肠腺癌有一定疗效,不良反应轻微,可耐受。

Abstract: Objective: To evaluate the therapeutic effect and side effect of high dose of cisplatin(HD DDP) combined with fluorouracil(5-Fu)/leucovorin(CF) plus medroxyprogesterone acetate(MPA) on advanced gastric and colorectal adenocarcinoma.Methods: Twenty three cases of advanced gastric adenocarcinoma cases and 14 cases of advanced colorectal adenocarcinoma were treated with HD-DDP+5-Fu/CF+MPA regimen.Results: Effectiveness was noted in 10 cases in gastric adenocarcinoma group and 5 cases in the other;the overall responses rate(CR+PR) was 40.5% and 35.7% respectively.The main side-effects were nausea and vomiting,which reached degree Ⅱ or higher(24.3%).BUN elevation was observed only in two cases.Conclusions: HD-DDP+5-Fu/CF+MPA regimen proves to be effective and its side-effects are slight and endurable.