The regulation effects of taurine on excitability of sciatic nerve trunk in the toads
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摘要: 目的: 观察牛磺酸对蟾蜍坐骨神经干兴奋性的影响。方法: 分离蟾蜍的坐骨神经干(50根),分5组,用含不同浓度CaCl2和牛磺酸的任氏液浸泡30min备用。用Medlab生物信号采集处理系统测定神经干的阈值、不应期和传导速度。结果: 与正常任氏液(1.09mmol/L)比较,高钙任氏液(2.18mmol/L)神经干的阈值升高,不应期缩短(P<0.01);低钙任氏液(0.27mmol/L)的神经干的阈值降低,不应期缩短,传导速度加快(P<0.05~P<0.01);而低钙加牛磺酸组及高钙加牛磺酸(40mmol/L)组上述变化均不明显(P>0.05)。结论: 牛磺酸可调节神经干的兴奋性。Abstract: Objective: To observe the effect of taurine on the excitation of the sciatic nerve trunk in vitro.Methods: The sciatic nerve trunks of toads were isolated and soaked in Ringer's solution containing different concentration of chloride calcium with taurine(40 mmol/L) for 30 minutes.The threshold,refractory period and conduction velocities of action potential were measured by computer.Results: Compared with the normal Ringer's solution group (1.09 mmol/L),the threshold increased and the refractory period shrinked in the Ringer's solution containing higher concentration of chloride calcium(2.18 mmol/L),while the threshold and the conduction velocity of action potential decreased,the refractory period shrinked in the lower concentration(0.27 mmol/L)(P<0.05-P<0.01).Above changes are unobvious in Ringer's solution containing taurine(40 mmol/L) with lower or higher concentration of chloride calcium(P>0.05).Conclusions: The taurine could regulate the excitability of the sciatic nerve trunk in vitro.
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Keywords:
- neural conduction /
- taurine toad /
- chloride calcium /
- toad action potentials /
- threshold
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