Objective To investigate the association between vascular age and subjective cognitive decline (SCD) in community population.

Methods A total of 143 residents in a community were selected as the study objects, and divided into the SCD group (81 cases, score ≥5 points) and control group (62 cases, score ＜ 5 points) according to the score of SCD-Q. The general information and biochemical findings between two groups were compared. According to the results of Framinham risk score (FRS) translating into vascular age, the difference between vascular age and actual age (age difference) was calculated, and the factors affecting SCD were analyzed.

Results The results of univariate analysis showed that the diastolic blood pressure and high density lipoprotein (HDL) level in the SCD group were lower than those in control group (P ＜ 0.05 and P ＜ 0.01), the levels of total cholesterol (TC), triacylglycerol and homocysteine (Hcy) and age difference in the SCD group were higher than those in control group (P ＜ 0.05 and P ＜ 0.01). The results of multivariate logistic regression analysis showed that the diastolic blood pressure, HDL, TC, Hcy and age difference were the independent influencing factors of SCD in community population (P ＜ 0.01).

Conclusions The prevalence of SCD in the community population is higher, and there is a correlation between the TC, TG, HDL, Hcy, diastolic blood pressure and age difference and incidence of SCD. The age difference can be used as one of the reference indexes for early monitoring and prevention of SCD in the community.