Curative effect of neoadjuvant chemotherapy and radiotherapy combined with operation in the treatment of cervical carcinoma
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摘要: 目的：分析术前行新辅助放化疗联合手术治疗FIGO Ib2~Ⅱb期宫颈癌患者的临床疗效。方法：对手术治疗的40例宫颈癌患者，术前行新辅助化疗1次，对于子宫颈病灶>4 ｃｍ，术前大出血者加腔内后装治疗1次。3周后行宫颈癌根治术。通过分析患者瘤体大小的改变、放化疗不良反应、手术难度的下降及术后病理改变等结果，评价新辅助放化疗在宫颈癌治疗中的安全性。结果：宫颈癌新辅助放化疗总有效率为82.5%，手术切除成功率为100%。结论：术前新辅助放化疗联合手术治疗宫颈癌Ib2~Ⅱb期患者安全有效，可提高手术的治疗效果，降低并发症发生率。Abstract: Objective: To explore the clinical efficiency of the preoperative neoadjuvant chemotherapy and radiotherapy combined with operation in the treatment of FIGO Ib-Ⅱb stage cervical carcinoma.Methods: Forty operation patients were treated with preoperative neoadjuvant chemotherapy and radiotherapy.the radical resections in the patients with cervical lesions more than 4 cm.preoperative massive hemorrhage treated with intracavitary brachytherapy after 3 weeks were implemented.The safety of neoadjuvant chemotherapy and radiotherapy was evaluated by the tumor size change,adverse reaction of chemotherapy and radiotherapy,operation difficulty change and postoperative pathological change.Results: The total effective rate and success rate of operation in the cervical carcinoma patients treated with neoadjuvant chemotherapy and radiotherapy were 82.5% and 100%,respectively.Conclusions: The neoadjuvant chemotherapy and radiotherapy combined with operation in treating the Ib2-Ⅱb stage cervical carcinoma is safe and effective.which can improve the operative effects and decrease the incidence of complications.
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Keywords:
- cervical neoplasm /
- neoplasm/radiotherapy /
- neoplasm/drug therapy /
- neoplasm/surgery
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