Abstract: Objective: To explore the clinical efficiency of the preoperative neoadjuvant chemotherapy and radiotherapy combined with operation in the treatment of FIGO Ib-Ⅱb stage cervical carcinoma.Methods: Forty operation patients were treated with preoperative neoadjuvant chemotherapy and radiotherapy.the radical resections in the patients with cervical lesions more than 4 cm.preoperative massive hemorrhage treated with intracavitary brachytherapy after 3 weeks were implemented.The safety of neoadjuvant chemotherapy and radiotherapy was evaluated by the tumor size change,adverse reaction of chemotherapy and radiotherapy,operation difficulty change and postoperative pathological change.Results: The total effective rate and success rate of operation in the cervical carcinoma patients treated with neoadjuvant chemotherapy and radiotherapy were 82.5% and 100%,respectively.Conclusions: The neoadjuvant chemotherapy and radiotherapy combined with operation in treating the Ib2-Ⅱb stage cervical carcinoma is safe and effective.which can improve the operative effects and decrease the incidence of complications.