Abstract: Objective:To evaluate the effect of non-invasive biphasic positive airway pressure (BIPAP) ventilation on post extubation respiration support the in patients with palatopharyngoplasty (PPP).Methods:Thirty patients with obstructive sleep apnea syndrome (OSAS) undergoing PPP post extubation in the post anaesthetic care unit (PACU) by non-invasive BIPAP ventilation.Systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR),pulse blood oxygen saturation (SpO₂) and end expiratory carbon dioxide partial pressure (PetCO₂) before or after non-invasive BIPAP were recorded.Results:Thirty patients with PPP post extubation wered received non-invasive BIPAP ventilation because of hypoxia and hypercapnia.SpO₂ increased and PetCO₂ decreased significantly after non-invasive BIPAP ventilation 30 minutes and one hour,compared with before non-invasive BIPAP ventilation,however,SBP,DBP,and HR had no difference before and after the non-invasive BIPAP ventilation.Conclusions:Non-invasive BIPAP ventilation is suitable for post extubation respiratory support in patients with OSAS post PPP because of hypoxia and hypercapnia in the PACU.