刘枭, 赵永清, 陈文香, 王辉. 苯巴比妥预防早产儿脑室内出血的疗效和安全性观察[J]. 蚌埠医学院学报, 2010, 35(10): 1030-1032.
    引用本文: 刘枭, 赵永清, 陈文香, 王辉. 苯巴比妥预防早产儿脑室内出血的疗效和安全性观察[J]. 蚌埠医学院学报, 2010, 35(10): 1030-1032.
    LIU Xiao, ZHAO Yong-qing, CHEN Wen-xiang, WANG Hui. Efficacy and safety of phenobarbital in preventing intraventricular hemorrhage in premature newborns[J]. Journal of Bengbu Medical College, 2010, 35(10): 1030-1032.
    Citation: LIU Xiao, ZHAO Yong-qing, CHEN Wen-xiang, WANG Hui. Efficacy and safety of phenobarbital in preventing intraventricular hemorrhage in premature newborns[J]. Journal of Bengbu Medical College, 2010, 35(10): 1030-1032.

    苯巴比妥预防早产儿脑室内出血的疗效和安全性观察

    Efficacy and safety of phenobarbital in preventing intraventricular hemorrhage in premature newborns

    • 摘要: 目的:观察苯巴比妥预防早产儿脑室内出血(intraventricular hemorrhage,IVH)的疗效以及安全性。方法:将胎龄≤ 35周、日龄<6 h的86例早产儿以单、双月收住院分为观察组49例和对照组37例,2组常规处理相同;观察组入院后即予苯巴比妥负荷量应用(20 mg/kg分2次缓慢静脉注射),24 h后给维持量应用(5 mg.kg-1·d-1分2次间隔12 h缓慢静脉注射),疗程5天。比较2组IVH和重度IVH以及呼吸暂停和反应低下的发生率。结果:观察组IVH的发生率为20.4%,较对照组37.8%降低(P<0.05)。观察组重度IVH的发生率为4.1%,对照组为8.1%;观察组呼吸暂停的发生率为34.7%,对照组为40.5%;观察组反应低下的发生率为24.5%,对照组为21.6%,差异均无统计学意义(P>0.05)。结论:苯巴比妥能有效预防早产儿IVH的发生,无严重不良反应,其应用是安全的。

       

      Abstract: Objective:To investigate the therapeutic efficacy and safety of phenobarbital in preventing premature newborns from intraventricular hemorrhage (IVH).Methods:Eighty-six premature newborns (≤ 35 weeks gestation and <6 hours post partum) were divided into treatment group (hospitalized in the singular month,n=49) and control group (hospitalized in the even month,n=37).Both groups received the same routine therapy.The patients in the treatment group were administered phenobarbital (20 mg/kg twice via intravenous drip) immediately after admission,followed by a course of 5 days' maintenance dosage (5 mg/kg intravenous drip with 12 hours interval) after 24 hours.The incidences of IVH,severe IVH,respiratory arrest and low response were compared between the two groups.Results:The phenobarbital treatment group had a significantly lower incidence of IVH (20.4%) than the control group (37.8%) (P<0.05).However,there was no difference in the incidence of severe IVH,respiratory arrest or low response between the treatment group (4.1%,34.7% and 24.5%,respectively) and the control group (8.1%,40.5% and 21.6%,respectively).Conclusions:Phenobarbital can effectively and safely prevent the incidence of IVH in premature newborns,and leaves no significant side effects.

       

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