Abstract: Objective: To observe the curative effect of 1% sodium hyaluronate(SH) injection in the treatment of osteoarthritis of the knee.Methods: SH injection was give 2 ml five times at intervals of one week through routine knee joint puncture,and compare Solu-Medrol sterile Powder(MP) injection was give 40 mg three times used the same ways.Results: The total effective rate was 94.2% after five weeks of etreatment in SH group.There was no recurrence of this disease in 88.4% of the patients 12 months after treatment.And in MP group,the total effective rate was 91.9%,83.8% of the patients who had been cured didn't recurrent after 12 months.Two groups is no significant difference(P>0.05).Conclusions: SH injection is an effective drug for treatment of osteoarthritis of the knee.Its tenderness relief and no poision or less side effect.