透明质酸钠治疗膝骨关节炎的临床体会

Clinical understand of sodium hyaluronate in the treatment of osteoarthritis of the knee

摘要: 目的: 观察1%透明质酸钠注射液对膝骨关节炎(OA)的疗效。方法: 常规膝关节注入透明质酸钠,每周1次,每次2 ml,连续5周,并与甲泼尼龙组对照,判定药物的疗效。结果: 治疗5周后,透明质酸钠组总有效率为94.2%,无明显毒副作用,停药1年后88.4%患者无复发。甲泼尼龙组总有效率为91.9%,停药1年后83.8%患者无复发。两组差异均无显著性(P>0.05)。结论: 透明质酸钠是治疗膝骨关节炎的有效药物,且疗效持久,无全身毒副作用。

Abstract: Objective: To observe the curative effect of 1% sodium hyaluronate(SH) injection in the treatment of osteoarthritis of the knee.Methods: SH injection was give 2 ml five times at intervals of one week through routine knee joint puncture,and compare Solu-Medrol sterile Powder(MP) injection was give 40 mg three times used the same ways.Results: The total effective rate was 94.2% after five weeks of etreatment in SH group.There was no recurrence of this disease in 88.4% of the patients 12 months after treatment.And in MP group,the total effective rate was 91.9%,83.8% of the patients who had been cured didn't recurrent after 12 months.Two groups is no significant difference(P>0.05).Conclusions: SH injection is an effective drug for treatment of osteoarthritis of the knee.Its tenderness relief and no poision or less side effect.