肺硬化性血管瘤2例报道及文献复习

    Sclerosing hemangiomas of lung: a report of 2 cases and review of the literature

    • 摘要: 目的:探讨肺硬化性血管瘤(SHL)的临床病理特征,提高诊断水平。方法:对2例SHL患者的临床病理资料进行回顾性分析,结合组织病理学和免疫组织化学法观察,并复习相关文献。结果:2例均为女性,临床表现为肺内孤立性肿块,镜下主要有4种类型:乳头型、实体型、硬化型和血管瘤样型,瘤细胞为多角形细胞和表面立方细胞,免疫表型表达细胞角蛋白、甲状腺转录因子-1、上皮膜抗原等。结论:SHL少见,可能起源于多潜能原始呼吸道上皮细胞,肿瘤具有特征性的组织学和免疫组化表现。

       

      Abstract: Objective: To investigate the features of sclerosing hemangiomas of lung(SHL) and improve diagnosis of SHL.Methods: Two cases of SHL were studied using routine histopathology(HE staining) and immunohistochemistry.Clinicopathological characteristics were then described and relevant literatures were reviewed.Results: Two cases were female.Tumors were solitary round or nearly round mass or nodule in lung.Under the microscope,four types of pathological manifestations,including papillary,solid,sclerolic and angiomatous,were found.The tumors consisted of two predominant cell types:pale polygonal cells and cuboid or columnar cells.Immunohistochemically,the cases were positive for cytokeretin,thyroid transcription factor and epithelial membrant antigen.Conclusions: SHL usually occur in female and is not easy to diagnosis clinically.It is suggested that SHL is an epithelial neoplasm derived from primitive respiratory epithelium.SHL have a characteristic appearance in microscopy and immunohistochemistry observation.

       

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