基于机器学习构建高龄产妇产后出血的预测模型

    Construction of a prediction model for postpartum hemorrhage in elderly parturients based on machine learning

    • 摘要:
      目的: 建立并验证高龄产妇产后出血(PPH)影响因素的预测模型,为早期识别和干预PPH提供科学依据。
      方法: 选取470例高龄产妇为研究对象,以最佳比例7∶3分配到训练集(329例)和验证集(141例)。基于最小绝对收缩与选择算子(LASSO)回归及多因素logistic筛选影响高龄产妇PPH的重要变量进行变量选择,并构建列线图预测模型;通过受试者工作特征(ROC)曲线、决策分析曲线(DCA)以及校准曲线验证模型的预测能力及临床价值。
      结果: 通过LASSO回归、多因素logistic筛选影响高龄产妇PPH的7个变量:年龄、前置胎盘、胎盘早剥、胎盘植入、妊娠期高血压疾病、巨大儿、D–D;并基于7个变量成功构建PPH的列线图预测模型,列线图在训练集和验证集中AUC值分别为:0.899(95%CI = 0.850 ~ 0.947,P < 0.05),0.903(95%CI = 0.850 ~ 0.957,P < 0.05)。校准曲线和Hosmer–Lemeshow拟合优度检验一致表明:该模型有较高的校准度(χ2 = 8.09,P > 0.05)。分别在训练集和验证集中绘制临床决策曲线显示:该预测模型具有良好的临床净收益率。
      结论: 年龄、前置胎盘、胎盘早剥、胎盘植入、妊娠期高血压疾病、巨大儿、D–D是影响高龄产妇PPH的重要变量,可为高龄产妇PPH的早期预测和干预提供科学依据。

       

      Abstract:
      Objective To establish and verify the a prediction model for the influencing factors of postpartum hemorrhage (PPH) in elderly parturient, and provide a scientific basis for early identification and intervention of PPH.
      Methods A total of 470 elderly parturients were selected as the research subjects, and divided into the training set (329 cases) and validation set (141 cases) in the optimal ratio of 7∶3. The important variables affecting PPH in elderly parturients were selected based on the minimum absolute contraction, selection operator (LASSO) regression and multivariate logistic screening, and a nomogram prediction model was constructed. The predictive ability and clinical value of the model were verified by the receiver operating characteristic (ROC) curve, decision analysis curve (DCA), and calibration curve.
      Results Seven variables affecting postpartum hemorrhage in elderly parturients were screened by LASSO regression and multivariate logistic regression: age, placenta previa, placental abruption, placental implantation, gestational hypertension, macrosomia and D-D. The nomogram prediction model of PPH was successfully constructed based on seven variables. The AUC values of the nomogram in the training set and the validation set were 0.899 (95%CI = 0.850–0.947, P < 0.05) and 0.903 ( 95%CI = 0.850–0.957, P < 0.05), respectively. The goodness-of-fit of the calibration curve was consisted with Hosmer Lemeshow, which indicated that the model had a relatively high calibration degree (χ2 = 8.09, P > 0.05). The results of the clinical decision curve in the training set and test set showed that the prediction model hds a good clinical net rate of return.
      Conclusions The age, placenta previa, placental abruption, placental implantation, gestational hypertension, macrosomia and D-D are important variables affecting PPH in elderly parturients, which can provide a scientific basis for early prediction and intervention of PPH in elderly parturients.

       

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