Abstract: Objective: To investigate the clinical effect of low ovarian chocolate cysts after mifepristone with GnRHa therapy. Methods: Ninety-seven cases that they were underwent laparoscopic cystectomy chocolate unilateral ovarian chocolate cysts were choosed, by the use of digital they were randomly divided into observation group 49 cases and control group 48 cases.Second day after operation observation group started low doses of oral mifepristone,10 mg/d, continued to take 3 months; and after the first menstrual cramps second day intramuscular GnRHa,3.75 mg every time,every 28 days,continuous injection of three times.Control group was injected GnRHa, treatment methods with the observation group.After 1 year,the treatment of two groups were compared,and the recording of adverse reactions observed appears.Results: After 1 year, the total effective rate and the recurrence rate of the observation group were 100.00% and 4.08% respectively;the total effective rate and the recurrence rate of the control group were 87.50% and 14.58%,respectively.The total efficiency and recurrence rate between the two groups were not significantly different(P>0.05).Before and after treatment between the two groups in serum FSH,LH,E2,P was not statistically significant (P>0.05);former levels of serum FSH,LH,E2,P level of treatment and treatment after comparison,FSH was significantly improved water,LH,E2,P levels were significantly reduced,and the differences were statistically significant(P<0.01).The incidence of adverse reaction in the observation group and the control group were 38.78% and 35.42%,was not statistically significant(P>0.05).Conclusions: Effect of low dose mifepristone combined with GnRHa treatment in chocolate cyst of ovary well after operation,the recurrence rate is low,and will help to improve ovarian function.