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    张颖, 顾尔伟. 氟比洛芬对心肺转流室间隔缺损患儿肿瘤坏死因子-α、白细胞介素-6的影响[J]. 蚌埠医科大学学报, 2011, 36(2): 142-144.
    引用本文: 张颖, 顾尔伟. 氟比洛芬对心肺转流室间隔缺损患儿肿瘤坏死因子-α、白细胞介素-6的影响[J]. 蚌埠医科大学学报, 2011, 36(2): 142-144.
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    ZHANG Ying, GU Er-wei. Effect of flurbiprofen on tumor necrosis factor-α,and interleukin-6 in children undergoing cardiopulmonary bypass[J]. Journal of Bengbu Medical University, 2011, 36(2): 142-144.
    Citation: ZHANG Ying, GU Er-wei. Effect of flurbiprofen on tumor necrosis factor-α,and interleukin-6 in children undergoing cardiopulmonary bypass[J]. Journal of Bengbu Medical University, 2011, 36(2): 142-144.
    shu

    氟比洛芬对心肺转流室间隔缺损患儿肿瘤坏死因子-α、白细胞介素-6的影响

    Effect of flurbiprofen on tumor necrosis factor-α,and interleukin-6 in children undergoing cardiopulmonary bypass

      摘要
    • 摘要: 目的:探讨氟比洛芬(flurbiprofen axetil,FA)对心肺转流(CPB)心内手术患儿血浆肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)水平的影响。方法:选择20例在CPB下行心内直视手术的室间隔缺损(ventricular septal defect,VSD)患儿,随机均分为FA组(F组)和对照组(C组)。F组在麻醉后切皮前15 min给予FA1 mg/kg,C组用等容量脂肪乳剂代替。分别于麻醉后切皮前10 min (基础值,T1)、主动脉开放10 min (T2)、CPB结束后30 min (T3)、4 h (T4)、24 h (T5)、48 h (T6)测定血浆TNF-α、IL-6水平。记录呼吸机辅助时间、围术期血管活性药物使用量等。结果:与T1相比,2组患者T3和T5时点TNF-α血浆水平均增高(P < 0.05~P < 0.01),F组在T3时点血浆浓度低于C组(P < 0.01)。与T1比较,C组在T2~6时点IL-6水平增高(P < 0.05~P < 0.01),F组在T2、T3和T6时点均较C组降低(P < 0.01)。患儿术后呼吸机辅助时间差异无统计学意义(P > 0.05);围术期多巴胺使用量差异有统计学意义(P < 0.05);术毕ICU留住时间差异无统计学意义(P > 0.05)。结论:FA可抑制CPB期间促炎性细胞因子TNF-α、IL-6的生成和释放,有助于患儿围术期血流动力学稳定,促进患儿早期康复。

       

      Abstract: Objective: To investigate the influence of flurbiprofen on cytokines tumor necrosis factor-α (TNF-α),and interleukin-6 (IL-6) in children undergoing cardiopulmonary bypass (CPB). Methods: In this pilot, prospective, and randomized double-blinded study,twenty children with cardiac function classⅠ-Ⅱ scheduled for repairing ventricular septal defect were divided into two groups:children in flurbiprofen group (F group,n=10) were received 1 mg/kg flurbiprofen 15 min before skin incision and children in control group (C group,n=10) were received 0.1 ml/kg intralipid instead of flurbiprofen. Blood samples were taken 10 min before skin incision (T1),10 min after aorta declamped (T2), 30 min (T3), 4 h (T4), 24 h (T5), 48 h (T6) after termination of CPB for determination of plasma TNF-α and IL-6 concentration. Results: The plasma TNF-α levels was higher at T3 and T5 compared to baseline (P < 0.05-P < 0.01),but F group was lower than in C group at T3 (P < 0.01). IL-6 was higher during T2-T6 in C group (P < 0.05-P < 0.01) compared to T1,but F group was lower than C group at T2,T3 and T6 (P < 0.01). Conclusions: Flurbiprofen is effective for reducing CPB-induced inflammatory response and it is benefitful for maintaining stability of circulation.

       

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