类风湿性关节炎与Ⅰ型胶原吡啶交联终肽的关系

Relationship between rheumatoid arthritis and pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen

摘要: 目的:探讨Ⅰ型胶原吡啶交联终肽(ICTP)在类风湿性关节炎(RA)患者外周血中的变化及其临床意义。方法:用酶标法检查45例RA组、31例骨关节炎(OA)组患者和32名健康人(对照组)的血清ICTP水平及RA组的血细胞沉降率(ESR)和C反应蛋白(CPR)水平。结果:RA组中ICTP浓度均显著高于对照组和OA组(P<0.01)。ICTP与ESR和CRP均有相关关系(P<0.01)。ICTP与RA患者X线分期无相关关系。结论:ICTP检测对RA诊断和判断病情活动情况有一定意义。

Abstract: Objective: To observe the change of pyridinoline cross-linked carboxy-terminal telopeptide type Ⅰ collagen(ICTP) in the serum of patients with rheumatoid arthritis(RA).Methods: The serum level of ICTP was determined in 45 patients with RA,31 patients with osteoarthritis(OA) and 32 healthy individuals by enzyme linked immunosorbent assay,and the erythrocyte sedimentation rate(ESR) and C reactive protein(CRP) of the 45 patients with RA were also detected.Results: The serum level of ICTP in the RA group was remarkably higher than that in the healthy and OA groups(P<0.01).The ICTP was directly correlated with ESR in the patients with RA and CRP(P<0.01),but had no relation with the radiogram staging(P>0.05).Conclusions: The serum level of ICTP in the patients with RA can reflect the progression of the disease.