金国玺, 王佑民. 空腹血糖受损人群干预后胰岛素抵抗与胰岛β细胞功能的改变[J]. 蚌埠医学院学报, 2009, 34(11): 969-971.
    引用本文: 金国玺, 王佑民. 空腹血糖受损人群干预后胰岛素抵抗与胰岛β细胞功能的改变[J]. 蚌埠医学院学报, 2009, 34(11): 969-971.
    JIN Guo-xi, WANG You-Ming. The changes of insulin resistance and pancreatic island function in cases with impaired fasting glucose received different interventions[J]. Journal of Bengbu Medical College, 2009, 34(11): 969-971.
    Citation: JIN Guo-xi, WANG You-Ming. The changes of insulin resistance and pancreatic island function in cases with impaired fasting glucose received different interventions[J]. Journal of Bengbu Medical College, 2009, 34(11): 969-971.

    空腹血糖受损人群干预后胰岛素抵抗与胰岛β细胞功能的改变

    The changes of insulin resistance and pancreatic island function in cases with impaired fasting glucose received different interventions

    • 摘要: 目的:观察空腹血糖受损者不同方法干预后的胰岛β细胞功能与胰岛素抵抗(IR)的改变情况,探讨空腹血糖受损(impaired fasting glucose,IFG)的发病机制与干预途径。方法:经葡萄糖耐量试验诊断的127例IFG随机分为3组:生活方式干预组(A组)41例,二甲双胍强化组(B组)45例,罗格列酮强化组(C组)41例。A组给予饮食和运动治疗,B组在此基础上加用二甲双胍治疗,C组加用罗格列酮治疗,在研究开始与结束时分别测量记录空腹血糖、2 h血糖、空腹胰岛素、2 h胰岛素,并在结束时复查葡萄糖耐量试验,比较各组胰岛β细胞功能与IR的改变情况。结果:A组的糖尿病转化率26.8%均高于B组和C组的6.7%与7.3%(P<0.05)。A组和B组的IR改善明显。结论:IFG的发病和IR有很大关系,二甲双胍或罗格列酮能更有效地改善IR,并减少IFG向糖尿病转化。

       

      Abstract: Objective: To investigate the changes of the function of pancreatic island and insulin resistance(IR) in cases with impaired fasting glucose(IFG) received different interventions.Methods: A total of 127 patients with IFG were divided randomly into three groups to be administrated with different interventions:life style intervention group(received dietary therapy and exercise training,n=41),plus metformin group(received dietary therapy and exercise training and metformin,n=45) and plus rosiglitazone group(received dietary therapy and exercise training and rosiglitazone,n=41).The body mass index,fasting plasma glucose,2 h plasma glucose,fasting insulin and 2 h insulin were measured both before and after the interventions.Finally,glucose tolerance tests recheck were and the changes of insulin resistance and pancreatic island function of each group were compared.Results: The rates of transformation of IFG to diabetes mellitus every year in plus metformin group(6.7%) and plus rosiglitazone group(7.3%) were significantly lower than that of life style intervention group(P<0.05).There were significantly improvements of insulin resistance in both of the two plus groups.Conclusions: The morbidity of IFG is closely related to the IR.Metformin or rosiglitazone can efficiently improve the IR and reduce the transformation of IFG to diabetes mellitus.

       

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