Abstract: Objective: To observe the feasibility of sevoflurane compound with propofol for anaesthesia used in children minimally invasive heart surgery.Methods: Fifty-six cases of children were undertaken intracardiac procedures with cardiopulmonary bypass.These cases were inducted with 4%-6% sevoflurane and O₂ inhalation,5 μg/kg of fentanyl and 0.06 mg/kg of midazolam through intravenous injection,vecuronium at 0.15 mg/kg were used in sequences for anaesthesia.Adopted 1.0%-2.5% sevoflurane inhalation compound with fentanyl and vecuronium to keep a good anaesthesia condition.Results: Fifty-six cases were kept a good anaesthesia effect which the process is steady,and blood pressure and heart rate were maintained steadily during operation(P>0.05).Mean arterial pressure(MAP),heart rate(HR) in post-CPB 1 minute,20 minutes were significantly lower than in pre-CPB(P<0.01).But MAP and HR in CPB shutdown compared with in pre-CPB no significant difference(P>0.05).The anaesthetizes relevant complications were not appeared after operation.Conclusions: Sevoflurane compound with propofol for anaesthesia can meet the demand in children minimally invasive heart surgery which is steadily and rapidly,and the anaesthesia profundity can be well controlled.