低剂量氟尿嘧啶联合小剂量顺铂治疗晚期胃癌疗效观察

Continuous venous infusion of low-dose of 5-fluorouracil and cisplatin for treatment of advanced gastric cancer

摘要: 目的: 评价低剂量氟尿嘧啶(5-Fu)持续输注联合小剂量顺铂(PDD)治疗晚期胃癌的疗效及其毒副作用。方法: 5-Fu250mg·m^-2·d^-1,通过便携式微量输液泵持续深静脉输注3周;PDD6mg·m^-2·d^-1,静脉输注1h,每周5天,连用3周,每4周为1周期。治疗2周期以上评价疗效及毒副作用。结果: 有效率为52.8%。初治和复治患者的疗效差异无统计学意义(P>0.05)。毒性反应主要为Ⅰ~Ⅱ度血液学毒性及胃肠道黏膜反应。结论: 低剂量5-Fu持续输注联合小剂量顺铂是治疗晚期胃癌的一种有效低毒的化疗方案,适用于晚期胃癌的治疗。

Abstract: Objective: To assess the efficacy and toxicity of a combination therapy of continuous venous infusion(civ) of low-dose of 5-fluorouracil(5-Fu)and cisplatin in treatment of advanced gastric cancer.Methods: The regimen consisted of 5-Fu 250 mg·m^-2·d^-1 civ,and PDD 6 mg·m^-2·d^-1,5 d/w,which were used for 3 weeks.The effect and the toxicity were evaluated after 2 cycles of treatment.Results: Gross efficiency rate was 52.8% in 1 the case of CR and 18 cases of PR.The Major toxic effect was gastrointestinal tract reaction.Repression of marrow was light.Conclusions: The chemotherapy regimen mentioned above is effective and has little toxic effect.It is suitable for treatment of advanced gastric cancer.