Abstract: Objective: To observe the effects of dexmedetomidine(DEX) injection before tracheal extubation on the anesthetic recovery of patients.Methods: Seventy-four thyroid surgery patients were randomly divided into the observation group and control group(37 cases each group).which were treated with 0.5 μg/kg of DEX for 10 min and 10 ml of 0.9% sodium chloride solution by intravenous infusion at 10 min after operation,respectively.The blood pressure,heart rate(HR),pulse oxygen saturation and the time of postoperative awake and extubation in two groups were compared,the adverse reactions(including cough,nausea and vomiting) before tracheal extubation,and postoperative 1 to 4 h Bruggrmann comfort score(BCS) and visual analogue scale(VAS) in two groups were observed.Results: The difference of the extubation time between two groups was not statistically significant(P >0.05).The HR in the observation group decreased after injecting DEX.Compared with the observation group,the incidence of cough in control group was high,and its BP and HR increased significantly at the time of extubation(P< 0.05 to P< 0.01).Compared with the observation group,the postoperative 1 to 4 h BCS and VAS in control group were low and high,respectively(P< 0.05).Conclusions: The DEX injection in thyroid surgery patients during extubation has good analgesic and sedative effects,which can effectively reduce the incidence of cough,and improve the comfortable degree of patients after operation.