非肥胖型与肥胖型多囊卵巢综合征的临床生化特征比较

周晓燕; 吴霞; 张琦

非肥胖型与肥胖型多囊卵巢综合征的临床生化特征比较

Comparison of the clinical and biochemical features of non-obese and obese women with polycystic ovary syndrome

摘要

摘要: 目的：探讨非肥胖型多囊卵巢综合征（PCOS）患者的临床生化特征。方法：将81例PCOS患者根据体质量指数（BMI）分为非肥胖组（BMI<25 kg/m²）和肥胖组（BMI≥25 kg/m²），比较2组患者临床与生化特征。结果：非肥胖组月经正常率为24.49%，肥胖组为5.9%；非肥胖组闭经率8.5%，肥胖组为26.5%；2组月经类型差异有统计学意义（P<0.05）；非肥胖组PCOS 患者卵泡刺激素（FSH）、黄体生成素（LH）、LH/FSH、高密度脂蛋白均高于肥胖组（P<0.05~P<0.01）；总睾酮、空腹血糖、空腹胰岛素、总胆固醇、三酰甘油和低密度脂蛋白均低于肥胖组（P<0.05~P<0.01）。结论：非肥胖的PCOS患者主要表现为下丘脑-垂体-卵巢轴功能紊乱，而肥胖的PCOS患者主要表为现胰岛素抵抗及血脂紊乱，临床诊治应个体化。

Abstract: Objective: To investigate the clinical and biochemical features of non-obese polycystic ovary syndrome(PCOS) patients.Methods: According to the body mass index(BMI),the 81 patients with PCOS were divided into the non-obese group(BMI<25 kg/m²) and obese group(BMI≥25 kg/m²),the clinical and biochemical features between two groups were compared.Results: The normal menstruation and amenorrhea rates in non-obese group and obese group were 24.49% & 5.9% and 8.5% & 26.5%,respectively,the differences of which were statistical significance(P<0.05).The levels of the follicle stimulating hormone(FSH),luteinizing hormone(LH),ratio of LH to FSH and high density lipoprotein cholesterol in non-obese group were higher than those in obese group(P<0.05 to P<0.01),the levels of the fasting plasma glucose,fasting insulin,total cholesterol,triglyceride and low density lipoprotein in non-obese group were significantly lower than those in obese group(P<0.05 to P<0.01).Conclusions: The non-obese PCOS patients are characterized by the dysfunction of hypothalamus-pituitary gland-ovary axis,the obese PCOS patients are characterized by the dysfunction of metabolism disorder of blood lipid and insulin resistance.The clinical diagnosis and treatment should be individualized.

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