喉癌患者血清中白细胞介素-18的检测意义

Significance of serum level of interleukin-18 in laryngeal cancer

摘要: 目的: 探讨血清白细胞介素-18(IL-18)的变化与喉癌的关系。方法: 采用双抗体夹心ELISA法检测22例喉癌患者(喉癌组)和10名健康者(对照组)血清中IL-18的含量。结果: 喉癌组血清IL-18含量为(68.44±39.42)pg/ml,明显高于对照组(28.47±2.29)pg/ml (P<0.001)。结论: 喉癌患者血清IL-18含量增高,可作为喉癌辅助诊断及观察患者病情变化的一项重要生化指标。

Abstract: Objective: To investigate the serum level of interleukin(IL)-18 in laryngeal cancer.Methods: The IL-18 concentration in sera was measured in 22 patients with laryngeal cancer,and 10 health control subjects by enzyme-linked immunosorbent assay(ELISA).Results: The concentration of IL-18 in patients with laryngeal cancer(68.44±39.42)pg/ml was significantly higher than that of health control subjects(28.47±2.29)pg/ml(P<0.001).Conclusions: The IL-18 is higher in patients with laryngeal cancer.The concentration of IL-18 may be an important biochemistry predictive sign in assistant diagnoses and monitoring the changes in patients with laryngeal cancer.