Abstract: Objective: To discuss the ways and measures of healthy education to ¹³¹Ⅰ therapeutic patients with differentiated thyroid cancer.Methods: The systematic and effective health education was conducted to 40 patients with differentiated thyroid cancer during the ¹³¹Ⅰ therapy period in hospital.Results: Forty patients were able to maintain a good mental state for ¹³¹Ⅰ therapy.It also prevented and reduced various side-effects induced by the ¹³¹Ⅰ therapy.The patient satisfaction rate reached 97%.Conclusions: Active and effective health education is beneficial to the implementation of ¹³¹Ⅰ therapy.It can also help relief the patients pain and improve their life quality.