Abstract: Objective: To analyze the effects of different nutrition modes on the glycemic control and gastrointestinal dysfunction in sepsis patients without gastrointestinal dysfunction.Methods: One hundred and thirty-eight sepsis patients were randomly divided into the enteral nutrition group and meal served nutrition group(69 cases each group).The enteral nutrition group and meal served nutrition group were treated with enteral nutrition liquid infusion and nutrition liquid meal served,respectively.The blood glucose control and incidence of gastrointestinal dysfunction between two groups were compared.Results: The incidence rates of hyperglycemia in enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 4.3% and 13.0%,respectively,the difference of which was not statistically significant(P>0.05).The difference of fasting blood glucose between two groups before nutritional support was not statistically significant(P>0.05).Compared with before the nutritional support,the blood glucose levels in two groups after 1 to 15 d of nutritional support increased significantly(P<0.01),the fasting blood glucose level in the enteral nutrient solution group after 1 to 15 d of nutritional support were lower than that in the meal served nutrition group(P<0.01).The incidences of gastrointestinal dysfunction in the enteral nutrient solution group and meal served nutrition group after 15 d of nutrition support were 5.8% and 15.9%,respectively,the difference of which was not statistically significant(P>0.05).Compared before nutrition support,the GIDF and SOFA scores in two groups after 15 d of nutrition support increased significantly(P<0.01).The GIDF and SOFA scores in the enteral nutrient solution group after 15 d of nutrition support were significantly lower than those in the meal served nutrition group(P<0.01).Pearson correlation analysis indicated that the GIDF score was positive correlation with SOFA score(P<0.01).Conclusions: The incidences of the hyperglycaemia and gastrointestinal dysfunction between two groups are similar.The continuing enteral nutrient solution has better effects on the energy supply and improving the prognosis of patients,which is the preferred way in nutritional support for patients with sepsis.