Abstract: Objective: To explore the clinicopathological features of plexiform neurofiroma(PNF).Methods: The clinical manifestatous and pathological charactors of 12 cases of PNF were observed and analysed combined with review of the literature.Results: PNF developed in childhood generally and often occurred at head and neck,limbs and trunks.The tumor appeared plexiform pattern consisted of Schwann cells,fibroblasts and collagen fibers.The spindle cells expressed S-100 protein diffusely and vimentin,EMA,NSE and NF scattered.Conclusions: PNF is a tumor with special clinicopathological characteristics,which is helpful to recognize the neurofibromatosis 1(NF1).