环磷酰胺联合大剂量甲泼尼龙治疗对百草枯中毒患者血清金属蛋白酶9水平的影响

Effect of cyclophosphamide combined with large doses of methylprednisolone on the serum level of matrix metalloproteinase 9 of patients with paraquat poisoning

摘要: 目的: 探讨环磷酰胺联合大剂量甲泼尼龙治疗对百草枯中毒患者血清金属蛋白酶9(MMP-9)水平的影响.方法: 选择急性百草枯中毒患者50例为研究对象,所有患者在常规治疗联合血液灌流基础上联合环磷酰胺及大剂量甲泼尼龙治疗.检测患者治疗前后血清MMP-9的变化.结果: 治疗后血清MMP-9 的水平均较治疗前明显降低(P< 0.01).结论: 环磷酰胺联合大剂量甲泼尼龙能有效降低百草枯中毒患者血清 MMP-9的水平,血清MMP-9水平降低可能是减轻肺损伤的机制之一.

Abstract: Objective: To explore the effects of cyclophosphamide combined with large doses of methylprednisolone on the serum level of matrix metalloproteinase 9(MMP-9) of patients with paraquat poisoning.Methods: Fifty patients with acute paraquat poisoning were treated with cyclophosphamide combined with large doses of methylprednisolone on the basis of additional treatment.The levels of serum MMP-9 in all patients were detected before and after treatment.Results: Compared with before treatment,the serum levels of MMP-9 in patients decreased significantly after treatment(P< 0.01).Conclusions: The treatment of cyclophosphamide combined with large doses of methylprednisolone can effectively reduce the serum levels of MMP-9 in patients with paraquat poisoning,which maybe one of the mechanisms of reducing lung injury.